Multi-step application of immobilized reagents and scavengers: a total synthesis of epothilone C.
نویسندگان
چکیده
The total synthesis of the cytotoxic antitumour natural product epothilone C has provided a stage for the exploitation and further development of immobilized reagent methods. A stereoselective convergent synthetic strategy was applied, incorporating polymer-supported reagents, catalysts, scavengers and catch-and-release techniques to avoid frequent aqueous work-up and chromatographic purification.
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ورودعنوان ژورنال:
- Chemistry
دوره 10 10 شماره
صفحات -
تاریخ انتشار 2004